Researchers Study Novel Proteins’ Role in Myelination

M. Laura Feltri, MD, professor of biochemistry and neurology, is leading research to determine whether a new family of molecules prevents demyelination and nerve degeneration in patients with peripheral nerve diseases. The research builds on her 2014 finding that the Continue reading Researchers Study Novel Proteins’ Role in Myelination

Researchers Identify Mutations In Charcot-Marie-Tooth Disease That Worsen Peripheral Nerve Damage

A combination of specific genetic mutations in Charcot-Marie-Tooth (CMT) disease that worsens peripheral nerve damage could be a helpful biomarker for predicting the severity of a given case of CMT, a Jackson Laboratory research team reports.

Either of two mutations impacting Scn8a — a sodium channel that is vital to the proper conduction of nerve impulses at the nodes of Ranvier — caused decreased sodium currents that led to severe neurological problems in the CMT mice, Burgess says. “These mutations, while innocuous on their own, can synergize with CMT-associated mutations to cause much more severe disease.” Continue reading Researchers Identify Mutations In Charcot-Marie-Tooth Disease That Worsen Peripheral Nerve Damage

Nerve signal discovery backs Nobel winner’s theory

Scientists have proved a 60-year-old theory about how nerve signals are sent around the body at varying speeds as electrical impulses.

Researchers tested how these signals are transmitted through nerve fibres, which enables us to move and recognise sensations such as touch and smell.

The findings from the University of Edinburgh have validated an idea first proposed by Nobel laureate Sir Andrew Huxley. Continue reading Nerve signal discovery backs Nobel winner’s theory

Turning Back The Clock For Schwann Cells

Myelin-making Schwann cells have an ability every aging Hollywood star would envy: they can become young again. According to a study appearing in the May 19 issue of the Journal of Cell Biology, David B. Parkinson (University College London, London, Continue reading Turning Back The Clock For Schwann Cells

Developmental loss of NT-3 in vivo results in reduced levels of myelin-specific proteins

Glia. 2008 Feb;56(3):306-17. Developmental loss of NT-3 in vivo results in reduced levels of myelin-specific proteins, a reduced extent of myelination and increased apoptosis of Schwann cells. Woolley AG, Tait KJ, Hurren BJ, Fisher L, Sheard PW, Duxson MJ. Department Continue reading Developmental loss of NT-3 in vivo results in reduced levels of myelin-specific proteins

1996 article from New York Times archives explains P0 mutation in Dejerine-Sottas

The New York Times recently digitized its pre-Internet archives and opened them to the public, so today I ran a search and found a single mention of Dejerine-Sottas disease. It’s an interesting article on the use of x-ray crystallography to Continue reading 1996 article from New York Times archives explains P0 mutation in Dejerine-Sottas

Critical Knowledge About The Nervous System Uncovered By Rutgers Scientists

Uncover the neural communication links involved in myelination, the process of protecting a nerve’s axon, and it may become possible to reverse the breakdown of the nervous system’s electrical transmissions in such disorders as multiple sclerosis, spinal cord injuries, diabetes Continue reading Critical Knowledge About The Nervous System Uncovered By Rutgers Scientists

Movies Reveal That the Process of Insulating Nerves Is Surprisingly Dynamic

The first time lapse movies of the initial stage of the process that wraps nerve fibers with an outer, insulating layer, published online on Nov. 12 in the journal Nature Neuroscience, are shedding new light on this complex process and Continue reading Movies Reveal That the Process of Insulating Nerves Is Surprisingly Dynamic

USC Researchers Closer To Cure For Multiple Sclerosis And Other Myelin-Related Diseases

Los Angeles – A breakthrough finding on the mechanism of myelin formation by Jonah Chan, assistant professor of cell and neurobiology at the Keck School of Medicine of the University of Southern California, could have a major impact on the Continue reading USC Researchers Closer To Cure For Multiple Sclerosis And Other Myelin-Related Diseases