Local anesthetics are effective for neuropathic pain

Lidocaine and similar local anesthetics are effective for treating pain that emanates from damaged nerves, according to a systematic review of current evidence. Neuropathic pain, which can occur with chronic diseases or conditions, is frequently unresponsive to treatment and worsens Continue reading Local anesthetics are effective for neuropathic pain

Effect of sodium channel blocker (mexiletine) on pathological ectopic firing pattern in a rat chronic constriction nerve injury model

J Orthop Sci. 2005;10(3):315-20. We studied the efficacy of mexiletine as a sodium channel blocker for neuropathic pain by investigating the effect of mexiletine on the pathological ectopic firing pattern in a chronic constriction nerve injury (CCI) model. The experiment Continue reading Effect of sodium channel blocker (mexiletine) on pathological ectopic firing pattern in a rat chronic constriction nerve injury model